Mandana Arbab, PhD

Manda Arbab is the Lodish Family Assistant Professor at the Rosamund Stone Zander Translational Neuroscience Center at Boston Children’s Hospital and Harvard Medical School Department of Neurology. Manda received her PhD in Regenerative Medicine at the Hubrecht Institute for Developmental Biology and Stem Cell Research and Utrecht University in The Netherlands where she worked on induced pluripotent stem cell modeling of motor neuron diseases and advancing CRISPR technologies. She went on to complete an NWO Rubicon postdoctoral fellowship at the Broad Institute of MIT and Harvard in the lab of Prof. David Liu where she developed a high-throughput genome-integrated platform to measure the activity of CRISPR tools at synthetic loci in mammalian cells. These data elucidated how target sequence features, DNA repair pathways, and genome editor characteristics affect genome editing outcomes, and enabled the development of predictive machine learning models of genome editing outcomes that facilitate precision genome editing strategy design. She has applied these insights to develop in vivo genome editing therapeutics to cure and treat genetic neurological disorders in cells and animal models of human disease.

She and her team continue to pursue their goal of developing novel genome editing therapeutics, translating these drugs from bench to bedside, and using genome editing technologies to uncover the pathogenic processes that underlie neurodegenerative diseases. In 2021, Manda was awarded the Pathway to Independence Award from the NIH National Institute of Neurological Disorders and Stroke.

Current group members

  • Kwangjun Lee

    Role Postdoctoral fellow

    Education PhD Biomedical Science, Florida State University

    Research interests I have created mutant cell and mouse models by CRISPR-mediated homology-directed repair to investigate functional short sequence motifs in circadian clock genes. My goal is to broaden my expertise in genome editing therapeutics, aiming to cure and treat genetic disorders in cell and animal models of human diseases.

    Hobbies I am a passionate sports fan. Currently, I enjoy playing tennis and golf. Additionally, I enjoy spending time at the gym and swimming to stay active and fit.

    Fun fact In 2022, I made a hole-in-one, we believed that it brings good fortune for three years! It is still valid!!

  • Andrea Bianchi

    Role Postdoctoral fellow

    Education PhD Translational and Molecular Medicine, Milan

    Research interests Genome editing is my passion. I transitioned to cancer immunology, exploring the role of B cells in cancer and became an expert in genetically modifying these cells for innovative cell therapies. My interests further include the tumor microenvironment mechanisms of aging.

    Hobbies Good food, organizing social gathering, perfume making.

    Favorite quote Your self respect has to be stronger than your feelings.

  • Mikey Chatigny

    Role Program Coordinator II

    Education B.S. Psychology/English

    Research interests: Neuropathology, Histology

    Hobbies: Reading, Writing, Gaming, Snowboarding

    Favorite quote: Everyone you meet is fighting a battle you know nothing about. Be kind. Always.

  • Jing headshot

    Jing Zhao

    Role Data Analyst

    Education M.S. in Bioinformatics from Northeastern University

    Research interests My work focuses on designing and optimizing computational workflows for high-throughput biological data analysis, including creating pipelines for CRISPR screening, and RNA-seq analysis, to solve complex biological problems and contribute to the understanding of human health, diseases, and genomics.

    Favorite activities Tennis and hiking.

    Favorite quote Work hard, play hard.

  • Magdalena headshot

    Magdalena Lang

    Role Graduate researcher

    Education Medicine and Biomedical Neuroscience Master’s at TU Munich

    Research interests Translating
    discoveries into clinical practice—especially in Neurology. I’m on a quest to understand how the brain and body tick.

    Favorite activity Dancing! Whether it's ballroom or in my kitchen waiting for something to bake, it’s my happy place.

    Fun fact I was one of the dancers who helped open the UEFA Euro Soccer
    Championship 2024. It was pretty epic!

  • Aliyah Dawkins

    Aliyah Dawkins

    Role: Rotating PhD Candidate, Program in Neuroscience

    Education: B.S. in Biochemistry and Behavioral Neuroscience from Western Washington University

    Research interests: I am passionate about investigating the molecular mechanisms underlying neurodegeneration, with a particular focus on how patient heterogeneity can inform the development of more personalized and effective therapeutics.

    Hobbies: Hiking, weightlifting, roller skating, and board games

    Fun fact: I currently hold the Women’s Indoor Pentathlon record at my undergraduate university (2025)

  • Zach Barsdale

    Zach Barsdale

    Role: Rotating Graduate Student

    Education: University of California—Berkeley

    Research interests: molecular and cellular neuroscience, neurodegenerative diseases, DNA damage and repair

    Hobbies: weightlifting, painting, ‘dog-dad’ing (golden retriever)

    Currently watching: Game of Thrones (again)

    Favorite quote: “I’m not 25 anymore, standing in front of a boulder like, ‘This has to move.’ You give what you can, but there’s beauty everywhere in every moment. You don’t have to build it. You don’t have to search for it.” - Donald Glover

  • Adrian Quintana

    Role: Research Assistant

    Education: B.A in Neuroscience and Latino & Latina Studies at Vanderbilt University

    Research interests: Neurodegenerative diseases, translational research especially in the field of neurology

    Hobbies: Running, Cooking

    Favorite activity: Sitting outside and soaking up the sun.

    Currently watching/reading: Modern Family

    Favorite quote: “You are made for this moment. You have what it takes to meet it and meet it you must.”

Lab outings

December 2024 - Level 99

Former group members

  • Marissa Sumathipala

    PhD Candidate, Program in Neuroscience

    Education Harvard College; Cambridge University

  • Ivy Nguyen - headshot

    Ivy Nguyen

    PhD Candidate in the Biological & Biomedical Sciences (BBS) at Harvard Medical School

    Education B.S in Biological Chemistry, Bates College

  • Junghyun Yoo - headshot

    Junghyun Yoo

    PhD Candidate, Program in Neuroscience

    Education University of California, Berkeley (BA in Molecular and Cell Biology, Neurobiology emphasis)

  • Joy Horng

    PhD Candidate, Biological and Biomedical Sciences program

    Education BSc in Chemistry, Northeastern University

  • Alanna Kirschner

    Research Assistant

    Education: B.S. from Bates College, Biochemistry and Minored in Religious Studies.

  • James Chacharone

    Research Assistant

    Education: B.S. in Chemistry from Wake Forest University

  • Lisa Diez

    Rotating PhD Candidate, Program in Neuroscience

    Education B.S. Double Major in Neural Science and Psychology, New York University

  • Adam Steven Eckardt

    Rotating Phd Candidate, Biological & Biomedical Sciences Program

    Education B.S. in Biochemistry & Pharmacology/Toxicology from the University of Wisconsin Madison