Mandana Arbab, PhD

Manda Arbab is the Lodish Family Assistant Professor at the Rosamund Stone Zander Translational Neuroscience Center at Boston Children’s Hospital and Harvard Medical School Department of Neurology. Manda received her PhD in Regenerative Medicine at the Hubrecht Institute for Developmental Biology and Stem Cell Research and Utrecht University in The Netherlands where she worked on induced pluripotent stem cell modeling of motor neuron diseases and advancing CRISPR technologies. She went on to complete an NWO Rubicon postdoctoral fellowship at the Broad Institute of MIT and Harvard in the lab of Prof. David Liu where she developed a high-throughput genome-integrated platform to measure the activity of CRISPR tools at synthetic loci in mammalian cells. These data elucidated how target sequence features, DNA repair pathways, and genome editor characteristics affect genome editing outcomes, and enabled the development of predictive machine learning models of genome editing outcomes that facilitate precision genome editing strategy design. She has applied these insights to develop in vivo genome editing therapeutics to cure and treat genetic neurological disorders in cells and animal models of human disease.

She and her team continue to pursue their goal of developing novel genome editing therapeutics, translating these drugs from bench to bedside, and using genome editing technologies to uncover the pathogenic processes that underlie neurodegenerative diseases. In 2021, Manda was awarded the Pathway to Independence Award from the NIH National Institute of Neurological Disorders and Stroke.

Current group members

  • Kwangjun Lee

    Role Postdoctoral fellow

    Education PhD Biomedical Science, Florida State University

    Research interests I have created mutant cell and mouse models by CRISPR-mediated homology-directed repair to investigate functional short sequence motifs in circadian clock genes. My goal is to broaden my expertise in genome editing therapeutics, aiming to cure and treat genetic disorders in cell and animal models of human diseases.

    Hobbies I am a passionate sports fan. Currently, I enjoy playing tennis and golf. Additionally, I enjoy spending time at the gym and swimming to stay active and fit.

    Fun fact In 2022, I made a hole-in-one, we believed that it brings good fortune for three years! It is still valid!!

  • Andrea Bianchi

    Role Postdoctoral fellow

    Education PhD Translational and Molecular Medicine, Milan

    Research interests Genome editing is my passion. I transitioned to cancer immunology, exploring the role of B cells in cancer and became an expert in genetically modifying these cells for innovative cell therapies. My interests further include the tumor microenvironment mechanisms of aging.

    Hobbies Good food, organizing social gathering, perfume making.

    Favorite quote Your self respect has to be stronger than your feelings.

  • Mikey Chatigny

    Role Program Coordinator II

    Education B.S. Psychology/English

    Research interests: Neuropathology, Histology

    Hobbies: Reading, Writing, Gaming, Snowboarding

    Favorite quote: Everyone you meet is fighting a battle you know nothing about. Be kind. Always.

  • Jing headshot

    Jing Zhao

    Role Data Analyst

    Education M.S. in Bioinformatics from Northeastern University

    Research interests My work focuses on designing and optimizing computational workflows for high-throughput biological data analysis, including creating pipelines for CRISPR screening, and RNA-seq analysis, to solve complex biological problems and contribute to the understanding of human health, diseases, and genomics.

    Favorite activities Tennis and hiking.

    Favorite quote Work hard, play hard.

  • Magdalena headshot

    Magdalena Lang

    Role Graduate researcher

    Education Medicine and Biomedical Neuroscience Master’s at TU Munich

    Research interests Translating
    discoveries into clinical practice—especially in Neurology. I’m on a quest to understand how the brain and body tick.

    Favorite activity Dancing! Whether it's ballroom or in my kitchen waiting for something to bake, it’s my happy place.

    Fun fact I was one of the dancers who helped open the UEFA Euro Soccer
    Championship 2024. It was pretty epic!

  • Zach Barsdale

    Zach Barsdale

    Role: Rotating Graduate Student

    Education: University of California—Berkeley

    Research interests: molecular and cellular neuroscience, neurodegenerative diseases, DNA damage and repair

    Hobbies: weightlifting, painting, ‘dog-dad’ing (golden retriever)

    Currently watching: Game of Thrones (again)

    Favorite quote: “I’m not 25 anymore, standing in front of a boulder like, ‘This has to move.’ You give what you can, but there’s beauty everywhere in every moment. You don’t have to build it. You don’t have to search for it.” - Donald Glover

  • Sara MacManus

    Education: BSc in Biochemistry at University of Massachusetts Amherst

    Role: Rotation Student

    Research interests: I am interested in investigating the genetic mechanism underlying disease, particularly neurological diseases, and applying that knowledge to develop therapeutic approaches

    Hobbies: Aerial silks, weightlifting, sewing my own clothes, going out with friends!

    Life goals: Travel to every continent, be able to do the splits, move to a new country and work in a lab there!

    Fun fact: I have been to 23 different countries

    Favorite activity: Biking at night during the summer

    Currently watching/reading: Currently re-watching Supernatural, and reading the Game of Thrones series

    Favorite quote: The “Analogy of the Fig Tree” from Sylvia Plath’s ‘The Bell Jar’

    Pet peeve: AC being turned on when it isn’t hot out

  • Adrian Quintana

    Role: Research Assistant

    Education: B.A in Neuroscience and Latino & Latina Studies at Vanderbilt University

    Research interests: Neurodegenerative diseases, translational research especially in the field of neurology

    Hobbies: Running, Cooking

    Favorite activity: Sitting outside and soaking up the sun.

    Currently watching/reading: Modern Family

    Favorite quote: “You are made for this moment. You have what it takes to meet it and meet it you must.”

  • Adam Eckardt

    Adam Eckardt

    Education: B.S. Pharmacology & Toxicology, B.S. Biochemistry, Certificate in Biocore

    Role: Harvard Biological & Biomedical Science (BBS) PhD Student

     Research interests: I am fascinated by the power of emerging gene editing technologies and their potential to reshape our approach to neurodegenerative disease. My work centers on engineering genetic tools that not only expand our understanding of disease biology but also lay the groundwork for future therapeutic breakthroughs.

     Hobbies: Chess, Golf & Powerlifting

    Currently watching/reading: Shadows of the apt

     Favorite quote: “Any sufficiently advanced technology is indistinguishable from magic” – Arthur C. Clarke

Lab outings

December 2024 - Level 99

Former group members

  • Aliyah Dawkins

    Current Position: PhD Candidate for Neuroscience Program

  • James Chacharone

    Current position: MD Student at UMass

  • Alanna Kirschner

    Current Position: PhD Student at University of Heidelberg

  • Lisa Diez

    Current Position: Graduate Student at Harvard Medical School

  • Ivy Nguyen - headshot

    Ivy Nguyen

    Current Position: Graduate Student at Harvard Medical School

  • Junghyun Yoo - headshot

    Junghyun Yoo

    Current Position: Graduate Student at Harvard Medical School

  • Marissa Sumathipala

    Current Position: Graduate Student at Harvard Medical School

  • Joy Horng

    Current Position: Harvard BBS PhD Program